Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain
IntroductionNeurosphere culture is widely used to expand neural stem and progenitor cells (NSPCs) of the nervous system.Understanding the identity of NSPCs, such as the principals involved in spatiotemporal patterning, will improve our chances of using NSPCs for neurodevelopmental and brain repair studies with the ability to direct NSPCs toward dis